Seventh Seltzer has done everything he can to break from the past, but in his overbearing, narcissistic mother's last moments he is drawn back into the life he left behind. At her deathbed, she whispers in his ear the two words he always knew she would: "Eat me."

This is not unusual, as the Seltzers are Cannibal-Americans, a once proud and thriving ethnic group, but for Seventh, it raises some serious questions, both practical and emotional. Of practical concern, his dead mother is six-foot-two and weighs about four hundred and fifty pounds. Even divided up between Seventh and his eleven brothers, that's a lot of red meat. Plus Second keeps kosher, Ninth is vegan, First hated her, and Sixth is dead. To make matters worse, even if he can wrangle his brothers together for a feast, the Can-Am people have assimilated, and the only living Cannibal who knows how to perform the ancient ritual is their Uncle Ishmael, whose erratic understanding of their traditions leads to conflict.

Seventh struggles with his mother's deathbed request. He never loved her, but the sense of guilt and responsibility he feels -- to her and to his people and to his "unique cultural heritage" -- is overwhelming. His mother always taught him he was a link in a chain, thousands of people long, stretching back hundreds of years. But, as his brother First says, he's getting tired of chains.